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Avana 100 mg (avanafil) interactions can potentially be dangerous if the medication is combined with certain other substances or medications. It's essential to be aware of these interactions to avoid adverse effects. Here are some considerations regarding interactions with Avana 100 mg:

Nitrates: Avanafil should never be taken with nitrates (such as nitroglycerin) used for treating chest pain (angina) or heart problems. The combination can lead to a severe drop in blood pressure, which can be life-threatening.

Alpha-blockers: Combining Avana 100 mg with alpha-blockers (medications used to treat high blood pressure or prostate conditions) can also cause a significant drop in blood pressure. It's important to adjust the dosage of avanafil if using alpha-blockers, under medical supervision.

Other PDE5 Inhibitors: Concurrent use of Avana 100 mg with other PDE5 inhibitors (like sildenafil, tadalafil, or vardenafil) is not recommended due to the additive effect on lowering blood pressure and potential risks of side effects.

Grapefruit Juice: Grapefruit juice can increase the levels of avanafil in the bloodstream, leading to potentially harmful effects. It's advisable to avoid grapefruit juice while taking Avana 100 mg.

Alcohol: While moderate alcohol consumption is generally acceptable with avanafil, excessive alcohol intake can increase the risk of side effects such as dizziness, lightheadedness, and low blood pressure. It's best to drink alcohol in moderation or avoid it altogether when taking Avana 100 mg.

To ensure safety and effectiveness, always inform your healthcare provider about all medications you are taking, including prescription, over-the-counter medications, herbal supplements, and vitamins. They can provide personalized advice on how to use Avana 100 mg safely and minimize the risk of interactions.