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Malegra 25 mg contains sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction. It's important to be aware of potential drug interactions to ensure safe use of Malegra 25 mg. Here are some notable interactions to consider:

Nitrates: Taking Malegra 25 mg with nitrates (commonly used to treat chest pain or angina) can cause a severe drop in blood pressure. This combination can lead to dizziness, fainting, or even a heart attack. Nitrates include medications such as nitroglycerin, isosorbide mononitrate, and isosorbide dinitrate.

Alpha-Blockers: These medications are used to treat high blood pressure or prostate enlargement (benign prostatic hyperplasia). Combining Malegra 25 mg with alpha-blockers can also cause a drop in blood pressure, leading to symptoms like dizziness, lightheadedness, and fainting. Alpha-blockers include medications such as doxazosin, prazosin, terazosin, and tamsulosin.

Antihypertensives: Other medications used to lower blood pressure (antihypertensives) can potentially interact with Malegra 25 mg to further decrease blood pressure. This interaction may lead to symptoms of low blood pressure, such as dizziness and fainting.

Protease Inhibitors: These medications are used to treat HIV/AIDS. They can increase the levels of sildenafil in the blood, potentially leading to an increased risk of sildenafil-related side effects.

Other PDE5 Inhibitors: Concurrent use of Malegra 25 mg with other PDE5 inhibitors (such as tadalafil, vardenafil, or another sildenafil-containing medication) is not recommended due to the potential additive effects on blood pressure and risk of side effects.

Grapefruit Juice: Grapefruit juice may increase the levels of sildenafil in the blood, potentially increasing the risk of side effects. It's advisable to avoid consuming grapefruit or grapefruit juice while taking Malegra 25 mg.

Other Medications: Always inform your healthcare provider about all medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements. Some medications may interact with sildenafil citrate, affecting how it works or increasing the risk of side effects.

It's crucial to discuss your full medical history and current medications with a healthcare provider before starting Malegra 25 mg or any sildenafil-containing medication. They can provide personalized guidance, monitor for potential interactions, and ensure safe and effective use of the medication for treating erectile dysfunction.