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Tadalista 40 mg contains tadalafil, which belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors. It works by inhibiting the enzyme phosphodiesterase type 5, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis. Mechanism of Action: Nitric Oxide Release: Sexual stimulation triggers the release of nitric oxide (NO) in the erectile tissue of the penis. Nitric oxide activates an enzyme called guanylate cyclase, which increases the production of cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). Smooth Muscle Relaxation: Increased levels of cGMP cause relaxation of the smooth muscle cells in the cavernous bodies of the penis and dilation of the blood vessels. This allows blood to flow into the penis more freely, leading to an erection. Erection Maintenance: Tadalafil helps maintain an erection by preventing the degradation of cGMP by the enzyme phosphodiesterase type 5. By inhibiting PDE5, Tadalista 40mg prolongs the effects of cGMP, allowing for sustained relaxation of the smooth muscle cells and prolonged blood flow into the penis. Key Points: Sexual Stimulation Required: Tadalista 40 mg, like other PDE5 inhibitors, does not produce an erection on its own. Sexual stimulation is necessary to initiate the release of nitric oxide and activate the biochemical pathway leading to erection. Duration of Action: Tadalafil has a longer duration of action compared to other PDE5 inhibitors, such as sildenafil (Viagra) or vardenafil (Levitra). It can remain effective for up to 36 hours after ingestion, earning it the nickname "the weekend pill." Onset of Action: Tadalista 40 mg typically starts working within 30 minutes to 1 hour after ingestion, although the onset may vary depending on individual factors such as metabolism, food intake, and dosage. Food Interaction: While tadalafil can be taken with or without food, consuming a heavy or high-fat meal may delay the onset of action. Tadalista 40 mg works by inhibiting the enzyme phosphodiesterase type 5, leading to increased levels of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis. This results in relaxation of the smooth muscle cells, dilation of blood vessels, and improved blood flow into the penis, ultimately facilitating an erection. It's important to take Tadalista 40 mg as directed by your healthcare provider and to understand that sexual stimulation is necessary for the medication to be effective.