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Fildena Double 200 mg is a medication used to treat erectile dysfunction (ED), and it contains sildenafil citrate as its active ingredient. Sildenafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor. While its primary action is not to directly influence nitric oxide levels, it does play a crucial role in the nitric oxide pathway in the body.

Here's how sildenafil citrate, present in Fildena Double 200 mg, interacts with the nitric oxide pathway:

Release of Nitric Oxide:

When a man experiences sexual arousal, the release of nitric oxide (NO) occurs in the erectile tissue of the penis. Nitric oxide then activates an enzyme called guanylate cyclase.
cGMP Production:

Guanylate cyclase converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP). Cyclic GMP is a signaling molecule that plays a key role in the relaxation of smooth muscle cells in the penile arteries.
Smooth Muscle Relaxation:

Increased levels of cGMP lead to the relaxation of smooth muscle cells in the penile arteries. This relaxation allows an increased blood flow to the erectile tissues of the penis, leading to an erection.
PDE5 Inhibition by Sildenafil Citrate:

Phosphodiesterase type 5 (PDE5) is an enzyme that breaks down cGMP. Sildenafil citrate, the active ingredient in Fildena Double 200 mg, inhibits PDE5. By doing so, it helps to prevent the degradation of cGMP, allowing it to accumulate and maintain its effects.
Extended Duration of Erection:

By inhibiting PDE5 and preserving cGMP levels, sildenafil citrate prolongs the duration of smooth muscle relaxation in the penile arteries. This results in an extended period during which the individual can achieve and maintain an erection in response to sexual stimulation.
It's important to note that the use of medications like Fildena Double 200 mg should be under the guidance of a healthcare professional. The dosage and usage instructions should be followed, and individuals with certain health conditions or those taking specific medications should consult with their healthcare provider before using such medications.