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When taking Malegra 25 mg, which contains sildenafil citrate, there are certain medications that should be avoided due to the potential for interactions. Interactions can lead to adverse effects or reduced effectiveness of Malegra 25 mg. It's essential to discuss your complete medication list with your healthcare provider to ensure your safety. Medications that should be avoided or used with caution when taking sildenafil (the active ingredient in Malegra 25 mg) include:Nitrates are commonly used to treat chest pain (angina) and certain heart conditions. Combining nitrates with sildenafil can lead to a dangerous drop in blood pressure, which can be life-threatening. This combination should be avoided at all costs. Medications used to treat high blood pressure (alpha-blockers) can interact with sildenafil, potentially causing a drop in blood pressure. If you are taking alpha-blockers, your healthcare provider may adjust the dose of Malegra 25 mg or suggest an alternative treatment. Using multiple medications for erectile dysfunction simultaneously is not recommended. Using Malegra 25 mg along with other ED medications, such as tadalafil or vardenafil, can increase the risk of side effects and complications. Riociguat is a medication used to treat pulmonary arterial hypertension. Combining it with Malegra 25 mg can lead to a significant drop in blood pressure.Medications that inhibit the CYP3A4 enzyme can increase the concentration of sildenafil in the blood, potentially leading to stronger or more prolonged effects. It's important to discuss any medications or substances that inhibit CYP3A4 with your healthcare provider. Grapefruit juice can also interact with sildenafil and increase its concentration in the blood. Avoid consuming grapefruit or grapefruit juice while taking Malegra 25 mg. Some antibiotics and antifungal medications can interact with sildenafil, potentially affecting its metabolism. It's important to inform your healthcare provider of any antibiotics or antifungal medications you are taking. Some HIV medications, particularly protease inhibitors, can affect the metabolism of sildenafil. Your healthcare provider can help manage these interactions if you are taking both HIV medications and Malegra 25 mg. Always consult with your healthcare provider and inform them of all medications, supplements, and medical conditions you have before starting any new medication, including Malegra 25 mg. They can provide guidance on potential interactions and ensure your safety.