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Tadarise, which contains tadalafil, is used to treat erectile dysfunction (ED) and sometimes benign prostatic hyperplasia (BPH). However, it is contraindicated in certain situations due to potential risks and adverse effects. Here are the main contraindications for using Tadarise: Nitrate Medications: Tadarise should not be used by individuals taking any form of nitrates, often prescribed for chest pain (angina), as the combination can lead to a dangerous drop in blood pressure. Examples include nitroglycerin, isosorbide mononitrate, and isosorbide dinitrate. Severe Cardiovascular Conditions: Individuals with significant heart conditions, such as recent heart attack (within the last 90 days), unstable angina, severe heart failure, or severe arrhythmias, should avoid using Tadarise due to the increased risk of cardiovascular events. Recent Stroke: Those who have had a stroke within the past six months should not use Tadarise, as it can increase the risk of adverse cardiovascular events. Severe Hypotension or Uncontrolled Hypertension: Tadarise is contraindicated in individuals with severe low blood pressure (hypotension) or uncontrolled high blood pressure (hypertension). Allergic Reactions: Individuals with a known allergy to tadalafil or any other ingredient in Tadarise should not take this medication. Severe Liver or Kidney Disease: Patients with severe hepatic impairment or severe renal impairment should avoid using Tadarise, or they may require dose adjustments and close monitoring by a healthcare provider. Retinitis Pigmentosa: This is a rare genetic eye disorder, and Tadarise can affect vision. Those with this condition should avoid using tadalafil. Use with Other PDE5 Inhibitors: Concurrent use of other phosphodiesterase type 5 (PDE5) inhibitors or ED treatments can increase the risk of adverse effects and should be avoided. Severe Deformities of the Penis: Individuals with conditions that predispose them to priapism (painful, prolonged erection), such as sickle cell anemia, multiple myeloma, or leukemia, or those with anatomical deformation of the penis (e.g., Peyronie's disease), should use Tadarise with caution. Precautions In addition to the contraindications, certain precautions should be taken: Interaction with Other Medications: Tadarise can interact with certain medications, such as alpha-blockers, antihypertensives, and some antifungal or antibiotic medications. Always inform your healthcare provider about all medications you are taking.

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